Elevation of cell cycle control proteins during spontaneous immortalization of human keratinocytes.
نویسندگان
چکیده
منابع مشابه
Telomerase induces immortalization of human esophageal keratinocytes without p16INK4a inactivation.
Normal human somatic cells have a finite life span and undergo replicative senescence after a limited number of cell divisions. Erosion of telomeric DNA has emerged as a key factor in senescence, which is antagonized during cell immortalization and transformation. To clarify the involvement of telomerase in the immortalization of keratinocytes, catalytic subunit of telomerase (hTERT) expression...
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ژورنال
عنوان ژورنال: Molecular Biology of the Cell
سال: 1993
ISSN: 1059-1524,1939-4586
DOI: 10.1091/mbc.4.2.185